abstract：:The aim of this work is the in vitro study of the late effects of single proton irradiation on HTB63 human melanoma cell growth, cell cycle and cell death. The experimental conditions were focused on analyzing the effects of irradiation on the periphery of tumour that can be, in clinical practice, close to critical or...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ristic-Fira A,Nikolic D,Petrovic I,Ruzdijic S,Raffaele L,Sabini MG,Cirrone GA,Cuttone G,Farruggia G,Masotti L,Kanazir DT

更新日期：2001-03-01 00:00:00

abstract：:The number of colorectal tumors per mouse induced by 1,2-dimethylhydrazine in transgenic (Tg) mice carrying human c-Ha-ras genes was significantly reduced by ingestion of apple pectin (AP) or a culture condensate of Bifidobacterium longum(MB) compared with a control diet and non-Tg mice. However, there were no differe...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ohno K,Narushima S,Takeuchi S,Itoh K,Itoh T,Hioki K,Nomura T

更新日期：2001-03-01 00:00:00

abstract：:In the present study we report twenty-nine patients with iatrogenic injuries and management during various operations for malignant conditions. The patients were reviewed in order to identify and study the incidence, type of treatment administered and outcome. The study group was composed of 29 patients with 31 iatrog...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Peker AE,Alagöl H,Ayyildiz A,Arik AI,Başay S

更新日期：2000-12-01 00:00:00

abstract：:The effect of malignant tumor growth on host's megakaryocytopoiesis and platelet production was studied in mice bearing transplantable Dalton's lymphoma. Tumor growth was paralleled by thrombocytosis, neutrophilia, and anemia. Platelet 51Cr half-life was normal but incorporation of 75Selenomethionine into circulating ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ray MR

更新日期：2000-12-01 00:00:00

abstract：:The renal oncocytoma is a solid epithelial neoplasm with a generally benign course. The improved image diagnostics with the computerized tomography (CT) and magnetic resonance imaging (MRI) should today permit the identification of these lesions preoperatively so that conservative rather than radical surgery can be em...

journal_title：Journal of experimental & clinical cancer research : CR

authors： De Carli P,Vidiri A,Lamanna L,Cantiani R

更新日期：2000-09-01 00:00:00

abstract：:We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

更新日期：2000-09-01 00:00:00

abstract：:Primary lymphoma of the breast is a rare disease that has been estimated to represent from 0.05% to 0.53% of all malignant breast tumors and approximately 2.2% of all extranodal lymphomas. The aim of this study is to review all cases of primary lymphoma of the breast at the Institute of Oncology and Radiology of Serbi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Babovic N,Jelic S,Jovanovic V

更新日期：2000-06-01 00:00:00

abstract：:Gastric tissue was transplanted from the fundic and pyloric mucosa of 8-week old female F344 rats into the duodenum of males. Autopsy, 12 months after the operation, revealed grafts associated with persistent stones in the duodenum and/or calcification in the tissue. Pepsinogen positive chimeric glands with goblet cel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Watanabe H,Ando Y,Uesaka T,Ishimura Y,Shiraki K,Lu H,Ohara M,Shoji S,Katoh O

更新日期：2000-06-01 00:00:00

abstract：:We report the long-term results of a series of patients affected by advanced epithelial ovarian cancer treated with the PEC combination (cisplatin 60 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 750 mg/m2, all at day 1, every 21 days). Response was evaluated after three cycles, and treatment continued in responsive...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Massacesi C,Bascioni R,Cellerino R,Scartozzi M,Bracci R,Alessandroni P,Antognoli S,Ciavattini A,De Nictolis M,Piga A

更新日期：2000-03-01 00:00:00

abstract：:Escherichia coli cytosine deaminase (CD), which is a prokaryotic enzyme, converts nontoxic prodrug 5-fluorocytosine (5-FC) into the toxic chemotherapeutic agent 5-fluorouracil (5-FU). To investigate an enzyme/prodrug gene therapy for colorectal cancer, using adenoviral gene transfer of the E. coli CD gene associated w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Koyama F,Sawada H,Fujii H,Hirao T,Ueno M,Hamada H,Nakano H

更新日期：2000-03-01 00:00:00

abstract：:A 41-year-old white homosexual man presented with epigastric pain and jaundice. Physical examination showed enlargement of bilateral axillar and left inguinal lymph node, while ERCP and a CT scan suggested interruption of bile flow in the intrapancreatic tract of the common bile duct. An endoprosthesis was positioned ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： De Toma G,Codacci-Pisanelli M,Nicolanti V,Plocco M,Caterino S,Perno CF

更新日期：1999-12-01 00:00:00

abstract：:The efficacy of currently developed methods for gene transfer into mammalian cells depends primarily on the transfection technique, and also on the type of targeted cells. Considering the importance of gene transfer in the creation of gene therapies, our study was aimed at the assessment of transfection capacity of re...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Novaković S,Knezević M,Golouh R,Jezersek B

更新日期：1999-12-01 00:00:00

abstract：:Renal cell carcinoma, in a high percentage of patients, metastasizes early, sometimes mimicking other lesions. We present a case of an asymptomatic papillary renal cell carcinoma that presented neck metastases as the initial manifestation. The laterocervical and supraclavicular masses were considered consistent with n...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Giuliani A,Caporale A,Borghese M,Galati G,Di Bari M,Demoro M

更新日期：1999-12-01 00:00:00

abstract：:Distant metastases (DM) is the point of concern and seems to be on the rise with the improved control of the laryngeal cancer in the primary site and neck regions. Prognostic factors must be evaluated to improve the detection of DM at early stage of the disease. Therefore, we have analyzed our cases of laryngeal squam...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yücel OT,Yilmaz T,Unal OF,Turan E

更新日期：1999-09-01 00:00:00

abstract：:We measured the serum level of soluble Fas (sFas) antigen in gastric MALT (mucosa-associated lymphoid tissue) lymphoma patients to investigate immune response of B lymphoma cells in gastric MALT lymphoma. The serum sFas antigen levels in 21 patients with Helicobacter pylori (HP)-positive MALT lymphoma were 4.51+/-0.25...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Doi T,Nishikawa Y,Endo H,Hosokawa Y,Tanimizu M,Hyodo I

更新日期：1999-09-01 00:00:00

abstract：:Increased expression of sialyl Lewis antigens, sLe(a) and sLe(x), is frequent during malignant transformation and tumor progression of gastrointestinal cancers and it is assumed to be correlated with the increased metastatic potential of tumor cells and, consequently, with poor patient survival. To determine the influ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Nakamori S,Nishihara S,Ikehara Y,Nagano H,Dono K,Sakon M,Narimatsu H,Monden M

更新日期：1999-09-01 00:00:00

abstract：:This case report describes a rare presentation of penile melanoma in which 3 successive primaries arose and were operated from an area of melanosis on the glans penis and prepuce. One of the major factors accounting for the poor prognosis of this patient was the long delay in presentation. This was largely due to the ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Testori A,Mazzarol G,Viale G,De Cobelli O,Lotti M,Rocco F,Andreoni B

更新日期：1999-06-01 00:00:00

abstract：:In the field of gut endocrinomas (carcinoids and relevant neoplasms), several classifications have been internationally accepted and utilized at varying frequency. The basis of the concepts regarding gut endocrinomas from which these classifications have been proposed were drawn from the different aspects. These inclu...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Yakuwa Y,Osaka M

更新日期：1999-03-01 00:00:00

abstract：:Over the past 20 years, fiberoptic endoscopy, followed by video-endoscopy, has taken on an increasingly important role in the diagnostics and therapy for digestive tract diseases. Especially in the field of oncology, endoscopy is fundamental not only for the diagnosis and staging of diseases of the gastroenteric tract...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Casale V,Lapenta R,Gigliozzi A,Villotti G

更新日期：1999-03-01 00:00:00

abstract：:Our previous studies have demonstrated the significant enzymatic activity of glycogen phosphorylase (GP) in the gastric carcinoma and proliferating cells of particular intestinal metaplasia (IM). This paper reviewed the identification of the GP isoform in the gastrointestinal carcinoma, and the investigation on the ro...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shimada S,Tashima S,Yamaguchi K,Matsuzaki H,Ogawa M

更新日期：1999-03-01 00:00:00

abstract：:To assess the relationship between serum concentrations of proinflammatory cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced NSCLC. Mean ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： De Vita F,Orditura M,Auriemma A,Infusino S,Catalano G

更新日期：1998-12-01 00:00:00

abstract：:This retrospective study analyzed specifically the predicting factors for radioresponse and survival in 74 supratentorial astrocytoma patients. As a result of this study, cytoreduction in terms of ODs to T1 or T0 stage level or pre-RT T1 tumor stage along with radioresponse has a positive impact on long-term survival....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Erkurt E,Tunali C,Erkişi M,Boyer B,Burgurt R

更新日期：1998-12-01 00:00:00

abstract：:The presence of NE-differentiation in the follicle-cell thyroid carcinoma has been investigated by immunohistochemical detection of chromogranin A in the neoplastic cells. It has been found that NE-differentiation was present in a significant percentage in the papillary Ca alone (46.60%) whereas all Huerthle-cell neop...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tseleni-Balafouta S,Kavantzas N,Alevizaki M,Paraskevakou H,Davaris P

更新日期：1998-12-01 00:00:00

abstract：:Two-year protocols are commonly used for long-term assay of chemicals for carcinogenicity. However, in some cases, if animals have been exposed to tested agent from the young age and sacrificed at the age of 2, an underestimation of the carcinogenic potential of non-genotoxic agents and tumor promoters is possible. Da...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Anisimov VN

更新日期：1998-09-01 00:00:00

abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Erhola M,Nieminen MM,Ojala A,Metsä-Ketelä T,Kellokumpu-Lehtinen P,Alho H

更新日期：1998-09-01 00:00:00

abstract：:Doxorubicin (DOX) has a wide spectrum of antitumor activity with dose-related cardiotoxicity as a major side effect. This cardiotoxicity has been suggested to result from the generation of oxygen-free radicals. The objective of the present study was to investigate the influence of the antioxidant, thymoquinone (TQ) on...

journal_title：Journal of experimental & clinical cancer research : CR

authors： al-Shabanah OA,Badary OA,Nagi MN,al-Gharably NM,al-Rikabi AC,al-Bekairi AM

更新日期：1998-06-01 00:00:00

abstract：:The role of viruses in the etiology of human oral cancer is critically reviewed. Available evidences show a positive correlation for human oral cancer with human papilloma virus (HPV), herpes simplex virus (HSV) and human herpes virus type-6 (HHV-6), having strongest association with HPV. These viruses may act alone o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Vasudevan DM,Vijayakumar T

更新日期：1998-03-01 00:00:00

abstract：:Tumours involving the scrotum are rare and primary malignant melanoma is among the rarest of these lesions. Between 1949 and 1996 only 7 cases have been reported. We present two cases of scrotal melanoma. The current recommendations and management strategies are discussed on the basis of a review of the literature. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Tandoğdu R,Ardjçoğlu A

更新日期：1998-03-01 00:00:00

abstract：:In a family consisting of 48 persons with high predisposition to familial stomach cancer (SCr), SCr was diagnosed in 8 persons (I-2; II-1,3,4; III-1,2,3,4). Moreover, one woman (III-8) had bilateral breast cancer and two (proband: IV-1 and her father's cousin: III-10) chronic gastritis. The proband, her father's cousi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Monakhov AS,Gulyaev AV,Savochkina IV,Hanson KP

更新日期：1997-12-01 00:00:00

abstract：:The Turcot syndrome has been defined as the simultaneous presence of multiple polyposis of the colon and a malignant brain tumor. This association is supposed to be genetically transmitted, even though we still do not exactly know whether this occurs in a dominant or recessive way. The case of a 47-year-old man submit...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fracasso P,Caviglia R,Grassi A,Lapenta R,Stigliano V,Franco D,Casale V

更新日期：1997-12-01 00:00:00

abstract：:Increased expression of CD44 variants is often observed in differentiated thyroid carcinomas. To establish a method for gene diagnosis of thyroid without any additional invasions to the patients, RNA in leftover cells inside the needle used for fine needle aspiration biopsies (FNABs) was extracted to detect the expres...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Takano T,Sumizaki H,Amino N

更新日期：1997-09-01 00:00:00

abstract：:In papillary thyroid carcinoma lymphnode metastases at presentation do not seem to adversely affect survival, but do increase the risk of loco-regional tumor recurrence. The value of systematic versus selective lymphadenectomy is far less standardized, whereas the role of postoperative radioiodine in preventing either...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ducci M,Appetecchia M,Marzetti M

更新日期：1997-09-01 00:00:00

abstract：:Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than tha...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Di X,Nishizaki T,Harada K,Kajiwara K,Nakayama H,Ito H

更新日期：1997-06-01 00:00:00

abstract：:Screening for ovarian cancer is an important step in improving ovarian cancer mortality. This is a report of screening for ovarian cancer using transvaginal sonography (TVS) on 2,095 asymptomatic women during the past four years. Ovarian tumors over 30 mm in diameter were detected in 87 women (4.2%). Fourteen tumors w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Misawa T,Asai M,Higashide K

更新日期：1997-06-01 00:00:00

abstract：:Seventeen adult urologic sarcomas treated at the Oncology Hospital of Ankara in the last ten-year period are described. There were six cases of paratesticular rhabdomyosarcoma (RMS), four cases of liposarcoma (LS), three cases of leiomyosarcoma (LMS); two cases of Kaposi sarcoma limited to glans penis, and only one pr...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Celebioğlu AS

更新日期：1997-03-01 00:00:00

abstract：:CML is characterized by a reciprocal translocation between the abl and bcr genes on chromosomes 9 and 22 and is usually diagnosed by the presence of the Philadelphia (Ph1) chromosome.However, the translocation may also occur without the appearance of the Ph1 chromosome. In this study the diagnostic efficiency of the m...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yazici H,Sengün Z,Aktan M,Aktuglu G,Uskent N,Dalay N

更新日期：1997-03-01 00:00:00